Incella’s technology: our thiol-yne based combinatorial click chemistry method allows parallel, high-throughput synthesis of hundreds of novel lipid-like chemicals in a cost effective manner. Every lipid-like molecule can be used to produce a novel transfection reagent with different properties.
We combine our expertise in chemistry and biology to create an interdisciplinary research and development environment that encompasses chemical design, synthesis, liposomal reagent preparation, cell-based screening assays as well as identification and final optimization of novel transfection reagents. With respect to the chemical synthesis, our proprietary thiol-yne based combinatorial click chemistry method allows parallel, high-throughput synthesis of hundreds of novel lipid-like chemicals. The method is cost effective, highly efficient with respect to chemical reactivity and product yield and, in addition, easy to perform under standard laboratory conditions. Our first “library” of novel lipid-like chemicals was created in March 2011 and over 10% of the synthesized molecules were found to be more efficient than the most widely used transfection reagent, Lipofectamine®2000 (Invitrogen) (Biomaterials 2012).
Strategic use of our technology for increased growth
- use of our technology: the technology is used to create large collections (libraries) of novel transfection reagents that are used in systematic screening assays to identify desirable products
The transfection reagent market can be divided into several niches based on the type of application or type of cells / organisms used. Out technology allows us to enter all these niches with minimal costs and efforts.
Incella plans to take full advantage of its current technology and resources in order to expand its product portfolio to include a range of transfection reagents that will meet the needs of researchers and pharmaceutical companies. The development of additional transfection reagent products is performed in a systematic manner, focusing on particular screening methods to identify transfection hits that can be quickly optimized for product launch.
More information about ScreenFect® transfection reagents can be found here.